Het-PDB Navi2 (PDB: 5CWA)

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Ligands
Code	Name	Link
0GA	3-{[(1z)-1-carboxyprop-1-en-1-yl]oxy}-2-hydroxybenzoic acid	PoSSuM
GOL	Glycerol	PoSSuM
SO4	Sulfate ion	PoSSuM
UNL	Unknown ligand	PoSSuM

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Download interaction data: 5CWA

Code :

5CWA PDBj RCSB PDB PDBe

Header :

Lyase/Lyase Inhibitor

Title :

Structure of Anthranilate Synthase Component I (TrpE) from Mycobacterium tuberculosis with inhibitor bound

Release Data :

2015-08-12

Compound :

mol_id	molecule	chains	synonym
1	Anthranilate synthase component 1	A	ASI
	ec: 4.1.3.27 mutation: H2D other_details: D TO H MUTATION FROM PUBLISHED SEQUENCE AT POSITION 2 DUE TO CLONING ARTEFACT, ALSO AFTER RTEV CLEAVAGE AN ADDITIONAL GA REMAINS ON CONSTRUCT USED PRIOR TO START M (NOT SHOWN IN SEQUENCE ABOVE)

Source :

mol_id	organism_scientific	expression_system
1	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) (taxid:83331)	Mycobacterium smegmatis (taxid:1772)
	strain: CDC 1551 / Oshkosh gene: trpE, MT1644

Authors :

Johnston, J.M., Bashiri, G., Evans, G.L., Lott, J.S., Baker, E.N.

Keywords :

Lyase, Inhibitor, Lyase-Lyase Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.10 Å )

Citation :

Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex.

Bashiri, G.,Johnston, J.M.,Evans, G.L. et al.
(2015) Acta Crystallogr.,Sect.D 71 : 2297 - 2308

Chain :

UniProt :

P9WFX2 (TRPE_MYCTO)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate	4.1.3.27	-
	-	-

PDB ID: 5CWA