Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CL Chloride ion
MG Magnesium ion
MES 2-(N-morpholino)-ethanesulfonic acid
Modified Residues
Code Name Link
02N 1-(4-methylphenyl)methanamine
54L Pent-4-ynoic acid
ACE Acetyl group
DPN D-phenylalanine
DPP Diaminopropanoic acid
Code : 5CGH
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Yeast 20S proteasome beta5-G48C mutant in complex with alpha-chloroacetamide 5
Release Data : 2015-12-02
Compound :
mol_id molecule chains synonym
1 Proteasome subunit alpha type-2 A,O Macropain subunit Y7,Multicatalytic endopeptidase complex subunit Y7,Proteasome component Y7,Proteinase YSCE subunit 7
ec: 3.4.25.1
mol_id molecule chains synonym
2 Proteasome subunit alpha type-3 B,P Macropain subunit Y13,Multicatalytic endopeptidase complex subunit Y13,Proteasome component Y13,Proteinase YSCE subunit 13
ec: 3.4.25.1
mol_id molecule chains synonym
3 Proteasome subunit alpha type-4 C,Q Macropain subunit PRE6,Multicatalytic endopeptidase complex subunit PRE6,Proteasome component PRE6,Proteinase YSCE subunit PRE6
ec: 3.4.25.1
mol_id molecule chains synonym
4 Proteasome subunit alpha type-5 D,R Macropain subunit PUP2,Multicatalytic endopeptidase complex subunit PUP2,Proteasome component PUP2,Proteinase YSCE subunit PUP2
ec: 3.4.25.1
mol_id molecule chains synonym
5 Proteasome subunit alpha type-6 E,S Macropain subunit PRE5,Multicatalytic endopeptidase complex subunit PRE5,Proteasome component PRE5,Proteinase YSCE subunit PRE5
ec: 3.4.25.1
mol_id molecule chains synonym
6 Probable proteasome subunit alpha type-7 F,T Macropain subunit C1,Multicatalytic endopeptidase complex subunit C1,Proteasome component C1,Proteinase YSCE subunit 1
ec: 3.4.25.1
mol_id molecule chains synonym
7 Proteasome subunit alpha type-1 G,U Macropain subunit C7-alpha,Multicatalytic endopeptidase complex C7,Proteasome component C7-alpha,Proteasome component Y8,Proteinase YSCE subunit 7,SCL1 suppressor protein
ec: 3.4.25.1
mol_id molecule chains synonym
8 Proteasome subunit beta type-2 H,V Macropain subunit PUP1,Multicatalytic endopeptidase complex subunit PUP1,Proteasome component PUP1,Proteinase YSCE subunit PUP1
ec: 3.4.25.1
mol_id molecule chains synonym
9 Proteasome subunit beta type-3 I,W Macropain subunit PUP3,Multicatalytic endopeptidase complex subunit PUP3,Proteasome component PUP3
ec: 3.4.25.1
mol_id molecule chains synonym
10 Proteasome subunit beta type-4 J,X Macropain subunit C11,Multicatalytic endopeptidase complex subunit C11,Proteasome component C11,Proteinase YSCE subunit 11
ec: 3.4.25.1
mol_id molecule chains synonym
11 Proteasome subunit beta type-5 K,Y Macropain subunit PRE2,Multicatalytic endopeptidase complex subunit PRE2,Proteasome component PRE2,Proteinase YSCE subunit PRE2
ec: 3.4.25.1
mutation: G48C
mol_id molecule chains synonym
12 Proteasome subunit beta type-6 L,Z Multicatalytic endopeptidase complex subunit C5,Proteasome component C5
ec: 3.4.25.1
mol_id molecule chains synonym
13 Proteasome subunit beta type-7 M,a Macropain subunit PRE4,Multicatalytic endopeptidase complex subunit PRE4,Proteasome component PRE4,Proteinase YSCE subunit PRE4
ec: 3.4.25.1
mol_id molecule chains synonym
14 Proteasome subunit beta type-1 N,b Macropain subunit PRE3,Multicatalytic endopeptidase complex subunit PRE3,Proteasome component PRE3,Proteinase YSCE subunit PRE3
ec: 3.4.25.1
mol_id molecule chains
15 carfilzomib-alpha-chloroacetamide 5 e,f
Source :
mol_id organism_scientific organism_common
1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
mol_id organism_scientific organism_common
2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
mol_id organism_scientific organism_common
3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
mol_id organism_scientific organism_common
4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
mol_id organism_scientific organism_common
5 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
mol_id organism_scientific organism_common
6 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
mol_id organism_scientific organism_common
7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
mol_id organism_scientific organism_common
8 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
mol_id organism_scientific organism_common
9 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
mol_id organism_scientific organism_common
10 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
mol_id organism_scientific organism_common
11 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
mol_id organism_scientific organism_common
12 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
mol_id organism_scientific organism_common
13 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
mol_id organism_scientific organism_common
14 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
mol_id organism_scientific
15 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Dubiella, C., Groll, M.
Keywords : HYDROLASE-HYDROLASE INHIBITOR complex, Proteasome, Mutant, Inhibitor, Binding Analysis
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Selective Inhibition of the Immunoproteasome by Structure-Based Targeting of a Non-catalytic Cysteine.

Dubiella, C.,Baur, R.,Cui, H.  et al.
(2015)  Angew.Chem.Int.Ed.Engl.  54 : 15888 - 15891

PubMed: 26563572
DOI: 10.1002/anie.201506631

Chain : A, O
UniProt : P23639 (PSA2_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : B, P
UniProt : P23638 (PSA3_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : C, Q
UniProt : P40303 (PSA4_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : D, R
UniProt : P32379 (PSA5_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : E, S
UniProt : P40302 (PSA6_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : F, T
UniProt : P21242 (PSA7_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : G, U
UniProt : P21243 (PSA1_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : H, V
UniProt : P25043 (PSB2_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : I, W
UniProt : P25451 (PSB3_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : J, X
UniProt : P22141 (PSB4_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : K, Y
UniProt : P30656 (PSB5_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : L, Z
UniProt : P23724 (PSB6_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : M, a
UniProt : P30657 (PSB7_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : N, b
UniProt : P38624 (PSB1_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.