Brand  (β version)

PDB ID: 5CG5

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Ligands
Code Name Style Show Link
DOD Deuterated water PoSSuM
MG Magnesium ion PoSSuM
RIS 1-hydroxy-2-(3-pyridinyl)ethylidene bis-phosphonic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5CG5   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBOTOR
Title : Neutron crystal structure of human farnesyl pyrophosphate synthase in complex with risedronate
Release Data : 2015-10-14
Compound :
mol_id molecule chains synonym
1 Farnesyl pyrophosphate synthase A FPS,(2E,6E)-farnesyl diphosphate synthase,Dimethylallyltranstransferase,Farnesyl diphosphate synthase,Geranyltranstransferase
ec: 2.5.1.10,2.5.1.1
fragment: UNP residues 74-419
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: FDPS, FPS, KIAA1293
Authors : Yokoyama, T., Mizuguchi, M., Ostermann, A., Kusaka, K., Niimura, N., Schrader, T.E., Tanaka, I.
Keywords : prenyl transferase, bisphophonate, osteoprosis, inhibitor, TRANSFERASE-TRANSFERASE INHIBOTOR complex
Exp. method : X-RAY DIFFRACTION ( 1.402 Å )
Citation :

Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase

Yokoyama, T.,Mizuguchi, M.,Ostermann, A.  et al.
(2015)  J.Med.Chem.  58 : 7549 - 7556

PubMed: 26314394
DOI: 10.1021/acs.jmedchem.5b01147

Reaction

Chain : A
UniProt : P14324 (FPPS_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
isopentenyl diphosphate + dimethylallyl diphosphate = (2E)- geranyl diphosphate + diphosphate 2.5.1.1 PubMed:16684881
-
isopentenyl diphosphate + (2E)-geranyl diphosphate = (2E,6E)- farnesyl diphosphate + diphosphate 2.5.1.10 PubMed:16684881
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:19309137
Binds 2 Mg(2+) ions per subunit.