Het-PDB Navi2 (PDB: 5AOM)

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Ligands
Code	Name	Link
FY8	N-(5-chloranyl-2-oxidanyl-phenyl)piperidine-4-carboxamide	PoSSuM
GOL	Glycerol	PoSSuM
ZN	Zinc ion	PoSSuM

Non-standard Residues
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Download interaction data: 5AOM

Code :

5AOM PDBj RCSB PDB PDBe

Header :

CELL CYCLE

Title :

Structure of the p53 cancer mutant Y220C with bound small molecule PhiKan883

Release Data :

2015-12-16

Compound :

mol_id	molecule	chains	synonym
1	CELLULAR TUMOR ANTIGEN P53	A,B	ANTIGEN NY-CO-13, PHOSPHOPROTEIN P53, TUMOR SUPPRESSOR P53, P53
	fragment: DNA-BINDING DOMAIN, UNP RESIDUES 94-312 mutation: YES

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:562)

Authors :

Joerger, A.C., Boeckler, F.M., Wilcken, R.

Keywords :

CELL CYCLE, P53, CANCER, TUMOR SUPPRESSION, DNA BINDING, CANCER THERAPY, SMALL-MOLECULE STABILIZERS, MOLECULAR CHAPERONE

Exp. method :

X-RAY DIFFRACTION ( 1.740 Å )

Citation :

Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53.

Joerger, A.C.,Bauer, M.R.,Wilcken, R. et al.
(2015) Structure 23 : 2246

PDB ID: 5AOM