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Ligands
Code Name Style Show Link
RJI 2,4,6-trioxo-1-phenyl-hexahydropyrimidine-5-carboxamide
Non-standard Residues
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Glycosylation
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Modification
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Code : 5ANK   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of CDK2 in complex with 2,4,6-trioxo-1-phenyl- hexahydropyrimidine-5-carboxamide processed with the CrystalDirect automated mounting and cryo-cooling technology
Release Data : 2016-04-13
Compound :
mol_id molecule chains synonym
1 CYCLIN-DEPENDENT KINASE 2 A CELL DIVISION PROTEIN KINASE 2, P33 PROTEIN KINASE
ec: 2.7.11.22
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_cell_line: Sf21
Authors : Zander, U., Hoffmann, G., Mathieu, M., Marquette, J.-P., Cornaciu, I., Cipriani, F., Marquez, J.A.
Keywords : TRANSFERASE, PROTEIN KINASE, INHIBITOR, AUTOMATED CRYSTAL HARVESTING, AUTOMATED CRYO-COOLING, CRYSTALDIRECT
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Automated Harvesting and Processing of Protein Crystals Through Laser Photoablation.

Zander, U.,Hoffmann, G.,Cornaciu, I.  et al.
(2016)  Acta Crystallogr.,Sect.D  72 : 454

PubMed: 27050125
DOI: 10.1107/S2059798316000954

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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