Brand  (β version)

PDB ID: 5ACW

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
RHU 4-methyl-5-(trifluoromethyl)-1,2,4-triazole-3-thiol PoSSuM
CL Chloride ion PoSSuM
OH Hydroxide ion PoSSuM
Non-standard Residues
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OCS Cysteinesulfonic acid
Glycosylation
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Structure summary

Code : 5ACW   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : VIM-2-1, Discovery of novel inhibitor scaffolds against the metallo- beta-lactamase VIM-2 by SPR based fragment screening
Release Data : 2015-11-04
Compound :
mol_id molecule chains
1 BETA-LACTAMASE A,B
ec: 3.5.2.6
Source :
mol_id organism_scientific expression_system
1 PSEUDOMONAS AERUGINOSA  (taxid:287) ESCHERICHIA COLI  (taxid:469008)
strain: 301-5473
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PDEST14
Authors : Christopeit, T., Carlsen, T.J.O., Helland, R., Leiros, H.K.S.
Keywords : HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.800 Å )
Citation :

Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 by Spr Based Fragment Screening

Christopeit, T.,Carlsen, T.J.O.,Helland, R.  et al.
(2015)  J.Med.Chem.  58 : 8671

PubMed: 26477515
DOI: 10.1021/ACS.JMEDCHEM.5B01289

Reaction

Chain : A, B
UniProt : Q9K2N0 (Q9K2N0_PSEAI)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 ARBA:ARBA00001526
-
Cofactor: Evidence: Note:
Zn(2+) ECO:0000256 | ARBA:ARBA00001947
-