Brand  (β version)

PDB ID: 5ZYK

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9MC 2-[4-[4-cyclopentyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol PoSSuM

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Structure summary

Code : 5ZYK   PDBj   RCSB PDB   PDBe
Header : LIPID TRANSPORT
Title : Crystal structure of CERT START domain in complex with compound E25
Release Data : 2019-02-27
Compound :
mol_id molecule chains synonym
1 LIPID-TRANSFER PROTEIN CERT A Ceramide transfer protein,hCERT,StAR-related lipid transfer protein 11
fragment: UNP residues 364-598
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: CERT
expression_system_strain: BL21(DE3)
expression_system_vector_type: pET28b
expression_system_plasmid: pET28b-His-3C-CERT START
Authors : Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Keywords : CERT, PH, START, COMPLEX, LIPID TRANSPORT
Exp. method : X-RAY DIFFRACTION ( 1.5500 Å )
Citation :

Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT

Nakao, N.,Ueno, M.,Sakai, S.  et al.
(2019)  Commun Chem 

DOI: 10.1038/s42004-019-0118-3

Reaction

Chain : A
UniProt : Q9Y5P4 (CERT_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
an N-acylsphing-4-enine(in) = an N-acylsphing-4-enine(out) - PubMed:15596449, PubMed:17591919, PubMed:18184806
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an N-acylsphinganine(in) = an N-acylsphinganine(out) - PubMed:15596449
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an N-acyl-(4R)-4-hydroxysphinganine(in) = an N-acyl-(4R)-4- hydroxysphinganine(out) - PubMed:15596449
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N-hexadecanoylsphing-4-enine(in) = N-hexadecanoylsphing-4- enine(out) - PubMed:15596449, PubMed:17392267, PubMed:18184806
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N-tetradecanoylsphing-4-enine(in) = N-tetradecanoylsphing-4- enine(out) - PubMed:15596449
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N-octadecanoylsphing-4-enine(in) = N-octadecanoylsphing-4- enine(out) - PubMed:15596449, PubMed:17392267, PubMed:18184806
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N-eicosanoyl-sphing-4-enine(in) = N-eicosanoyl-sphing-4- enine(out) - PubMed:15596449, PubMed:17392267
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N-(docosanoyl)-sphing-4-enine(in) = N-(docosanoyl)-sphing-4- enine(out) - PubMed:15596449
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N-(15Z-tetracosenoyl)-sphing-4-enine(in) = N-(15Z- tetracosenoyl)-sphing-4-enine(out) - PubMed:15596449
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N-hexadecanoylsphinganine(in) = N- hexadecanoylsphinganine(out) - PubMed:15596449
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N-hexadecanoyl-(4R)-hydroxysphinganine(in) = N-hexadecanoyl- (4R)-hydroxysphinganine(out) - PubMed:15596449
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