Het-PDB Navi2 (PDB: 5ZWJ)

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Ligands
Code	Name		Style	Show	Link
9LL	(2r)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2h-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide				PoSSuM

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Download interaction data: 5ZWJ

Code :

5ZWJ PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of EGFR 675-1022 T790M/C797S/V948R in complex with EAI045

Release Data :

2018-07-25

Compound :

mol_id	molecule	chains	synonym
1	Epidermal growth factor receptor	A	Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
	ec: 2.7.10.1 mutation: T790M, C797S, V948R

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: EGFR, ERBB, ERBB1, HER1

Authors :

Zhao, P., Yun, C.H.

Keywords :

EGFR T790M, C797S, EAI045, SIGNALING PROTEIN, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.900 Å )

Citation :

Crystal structure of EGFR T790M/C797S/V948R in complex with EAI045.

Zhao, P.,Yao, M.Y.,Zhu, S.J. et al.
(2018) Biochem. Biophys. Res. Commun. 502 : 332 - 337

Chain :

UniProt :

P00533 (EGFR_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:15374980, PubMed:17349580, PubMed:18046415, PubMed:18227510, PubMed:19560417, PubMed:19563760
	-

PDB ID: 5ZWJ