Het-PDB Navi2 (PDB: 5ZWH)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
9KX	(2s)-2-[(1r,3as,4e,7ar)-7a-methyl-4-[2-[(3r,5r)-4-methylidene-3,5-bis(oxidanyl)cyclohexylidene]ethylidene]-2,3,3a,5,6,7-hexahydro-1h-inden-1-yl]oct-4,6-diene-3-one				PoSSuM
9N9	(E,2s)-2-[(1r,3as,4e,7ar)-7a-methyl-4-[2-[(3r,5r)-4-methylidene-3,5-bis(oxidanyl)cyclohexylidene]ethylidene]-2,3,3a,5,6,7-hexahydro-1h-inden-1-yl]oct-6-en-4-yn-3-one				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 5ZWH

Code :

5ZWH PDBj RCSB PDB PDBe

Header :

HORMONE

Title :

Covalent bond formation between histidine of Vitamin D receptor (VDR) and a full agonist having an ene-ynone group via conjugate addition reaction

Release Data :

2018-07-18

Compound :

mol_id	molecule	chains	synonym
1	Vitamin D3 receptor	A	VDR,1,25-dihydroxyvitamin D3 receptor,Nuclear receptor subfamily 1 group I member 1
	mutation: 165-211 deletion

mol_id	molecule	chains
2	13-meric peptide from DRIP205 NR2 BOX peptide	C

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Rattus norvegicus (taxid:10116)	Rat	Escherichia coli (taxid:562)
	gene: Vdr, Nr1i1

mol_id	organism_scientific	expression_system
2	Homo sapiens (taxid:9606)	Synthetic construct (taxid:32630)

Authors :

Yoshizawa, M., Itoh, T., Anami, Y., Kato, A., Yoshimoto, N., Yamamoto, K.

Keywords :

HORMONE covalent modifier transcription factor VitaminD3 enone Michael addition electrophile, HORMONE

Exp. method :

X-RAY DIFFRACTION ( 2.38 Å )

Citation :

Identification of the Histidine Residue in Vitamin D Receptor That Covalently Binds to Electrophilic Ligands

Yoshizawa, M.,Itoh, T.,Hori, T. et al.
(2018) J. Med. Chem. 61 : 6339 - 6349

PDB ID: 5ZWH