Brand  (β version)

PDB ID: 5ZTO

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Ligands
Code Name Style Show Link
9JO N-{trans-4-[3-(2-chlorophenyl)-7-{[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-D]pyrimidin-1(2h)-yl]cyclohexyl}propanamide PoSSuM
CL Chloride ion PoSSuM
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Structure summary

Code : 5ZTO   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of EGFR 696-1022 T790M/C797S in complex with D3003
Release Data : 2019-06-12
Compound :
mol_id molecule chains synonym
1 Epidermal growth factor receptor A Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
ec: 2.7.10.1
mutation: T790M, C797S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: EGFR, ERBB, ERBB1, HER1
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
Authors : Zhu, S.J., Yun, C.H.
Keywords : EGFR, T790M/C797S, inhibitor, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.649 Å )
Citation :

Crystal structure of EGFR 696-1022 T790M/C797S in complex with D3003

Zhu, S.J.,Yun, C.H.
To Be Published 

Reaction

Chain : A
UniProt : P00533 (EGFR_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:15374980, PubMed:17349580, PubMed:18046415, PubMed:18227510, PubMed:19560417, PubMed:19563760
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