Brand  (β version)

PDB ID: 5ZTN

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Ligands
Code Name Style Show Link
CUR (1z,4z,6e)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one PoSSuM
Non-standard Residues
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PTR O-phosphotyrosine
SEP Phosphoserine
Glycosylation
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Structure summary

Code : 5ZTN   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : The crystal structure of human DYRK2 in complex with Curcumin
Release Data : 2018-07-18
Compound :
mol_id molecule chains
1 Dual specificity tyrosine-phosphorylation-regulated kinase 2 A,B
ec: 2.7.12.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: DYRK2
expression_system_strain: BL21(DE3)
Authors : Ji, C.G., Xiao, J.Y.
Keywords : inhibitor of kinase, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.496 Å )
Citation :

Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2.

Banerjee, S.,Ji, C.,Mayfield, J.E.  et al.
(2018)  Proc. Natl. Acad. Sci. U.S.A.  115 : 8155 - 8160

PubMed: 29987021
DOI: 10.1073/pnas.1806797115

Reaction

Chain : A, B
UniProt : Q92630 (DYRK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.12.1 PubMed:22998443
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.12.1 PubMed:22998443
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ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.12.1 PubMed:22998443
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