Brand  (β version)

PDB ID: 5ZOB

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Ligands
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Non-standard Residues
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Glycosylation
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Modification
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2UE 1-[4-(2-oxoethyl)benzyl]guanidine
00S 4-(aminomethyl)benzenecarboximidamide

Structure summary

Code : 5ZOB   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal structure of Zika NS3 protease with 4-guanidinomethyl-phenylacetyl-Arg-Arg-Arg-4-amidinobenzylamide
Release Data : 2018-10-17
Compound :
mol_id molecule chains synonym
1 Serine protease subunit NS2B A,C,G,E NS2B cofactor
ec: 3.4.21.91,3.6.1.15,3.6.4.13
mol_id molecule chains
2 NS3 protease B,D,H,F
mol_id molecule chains
3 4-guanidinomethyl-phenylacetyl-Arg-Arg-Arg-4-amidinobenzylamide I,J
Source :
mol_id organism_scientific organism_common expression_system
1 Zika virus  (taxid:64320) ZIKV Escherichia coli  (taxid:562)
strain: Mr 766
mol_id organism_scientific organism_common expression_system
2 Zika virus (strain Mr 766)  (taxid:64320) ZIKV Escherichia coli  (taxid:562)
strain: Mr 766
gene: GP1, A2G93_63394gpGP1
mol_id organism_scientific
3 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Phoo, W.W., Wirawan, M.
Keywords : Viral protease, Serine protease, non-structural protein 3, Zika protease, VIRAL PROTEIN, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.000 Å )
Citation :

Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors.

Phoo, W.W.,Zhang, Z.,Wirawan, M.  et al.
(2018)  Antiviral Res.  160 : 17 - 24

PubMed: 30315877
DOI: 10.1016/j.antiviral.2018.10.006

Reaction

Chain : A, C, G, E
UniProt : Q32ZE1 (POLG_ZIKV)
Reaction: EC: Evidence:
Physiological Direction:
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala. 3.4.21.91 -
-
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.48 PROSITE-ProRule:PRU00539, PubMed:31090058
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a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 3.6.1.15 -
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ATP + H2O = ADP + H(+) + phosphate 3.6.4.13 UniProtKB:Q9Q6P4
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a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L- homocysteine 2.1.1.56 PROSITE- ProRule:PRU00924
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a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S- adenosyl-L-homocysteine 2.1.1.57 PROSITE-ProRule:PRU00924
-
Chain : B, D, H, F
UniProt : A0A142IX72 (A0A142IX72_ZIKV)
Reaction: EC: Evidence:
Physiological Direction:
ATP + H2O = ADP + H(+) + phosphate 3.6.4.13 ARBA:ARBA00001556
-
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala. 3.4.21.91 ARBA:ARBA00024468
-
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 3.6.1.15 ARBA:ARBA00001491
-