Brand  (β version)

PDB ID: 5ZKQ

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Ligands
Code Name Style Show Link
9EU 4-ethynyl-3-{3-fluoro-4-[(2-methyl-1h-imidazo[4,5-C]pyridin-1-yl)methyl]benzene-1-carbonyl}-N,N-dimethyl-1h-indole-1-carboxamide PoSSuM
OLC (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate PoSSuM
SO4 Sulfate ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 5ZKQ   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Crystal structure of the human platelet-activating factor receptor in complex with ABT-491
Release Data : 2018-06-20
Compound :
mol_id molecule chains synonym
1 Platelet-activating factor receptor,Endolysin,Endolysin,Platelet-activating factor receptor A,B PAFr, Lysis protein, Lysozyme, Muramidase
ec: 3.2.1.17
mutation: F116Y, N169D, A230D,C97A, I137R, A230D, V234A, D289N
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: PTAFR, PAFR
Authors : Cao, C., Zhao, Q., Zhang, X.C., Wu, B.
Keywords : G protein-coupled receptor, Platelet-activating factor receptor, Complex, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

Structural basis for signal recognition and transduction by platelet-activating-factor receptor.

Cao, C.,Tan, Q.,Xu, C.  et al.
(2018)  Nat. Struct. Mol. Biol.  25 : 488 - 495

PubMed: 29808000
DOI: 10.1038/s41594-018-0068-y

Reaction

Chain : A, B
UniProt : P25105 (PTAFR_HUMAN)
Reaction : -
Chain : A, B
UniProt : P00720 (ENLYS_BPT4)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3.2.1.17 HAMAP-Rule:MF_04110, PubMed:4865643
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