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PDB ID: 5ZJ9

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
9E6 5-chloro thiophene-3-carboxylic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5ZJ9   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : human D-amino acid oxidase complexed with 5-chlorothiophene-3-carboxylic acid
Release Data : 2018-10-10
Compound :
mol_id molecule chains synonym
1 D-amino-acid oxidase A,B,C,D DAO
ec: 1.4.3.3
fragment: UNP residues 1-240
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: DAO, DAMOX
Authors : Kato, Y., Hin, N., Maita, N., Thomas, A.G., Kurosawa, S., Rojas, C., Yorita, K., Slusher, B.S., Fukui, K., Tsukamoto, T.
Keywords : D-amino acid, flavoenzyme, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Structural basis for potent inhibition of d-amino acid oxidase by thiophene carboxylic acids

Kato, Y.,Hin, N.,Maita, N.  et al.
(2018)  Eur J Med Chem  159 : 23 - 34

PubMed: 30265959
DOI: 10.1016/j.ejmech.2018.09.040

Reaction

Chain : A, B, C, D
UniProt : P14920 (OXDA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a D-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+) 1.4.3.3 PubMed:16616139, PubMed:17088322, PubMed:17303072, PubMed:18544534, PubMed:20567862, PubMed:20603179, PubMed:22203986, PubMed:23219954, PubMed:23391306, PubMed:25030849, PubMed:25701391, PubMed:29274788, PubMed:29326945, PubMed:30938755, PubMed:31799256, PubMed:32730563, PubMed:33484270, PubMed:34041270, PubMed:37558109, PubMed:38035964, PubMed:20368421
left-to-right
D-alanine + O2 + H2O = pyruvate + H2O2 + NH4(+) - PubMed:16616139, PubMed:20567862, PubMed:20603179, PubMed:22203986, PubMed:23219954, PubMed:23391306, PubMed:25701391, PubMed:29326945, PubMed:31799256, PubMed:32730563, PubMed:33484270, PubMed:34041270, PubMed:37558109, PubMed:38035964
left-to-right
D-cysteine + O2 + H2O = 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+) - PubMed:29326945, PubMed:31799256
left-to-right
D-dopa + O2 + H2O = 3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+) - PubMed:17088322, PubMed:17303072, PubMed:29326945
left-to-right
D-leucine + O2 + H2O = 4-methyl-2-oxopentanoate + H2O2 + NH4(+) - PubMed:20567862
left-to-right
D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + H2O2 + NH4(+) 1.4.3.3 UniProtKB:P00371
left-to-right
D-methionine + O2 + H2O = 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+) - UniProtKB:P00371
left-to-right
D-phenylalanine + O2 + H2O = 3-phenylpyruvate + H2O2 + NH4(+) - PubMed:20567862
left-to-right
D-proline + O2 = 1-pyrroline-2-carboxylate + H2O2 - PubMed:16616139, PubMed:30938755, PubMed:32730563, PubMed:38035964
left-to-right
D-serine + O2 + H2O = 3-hydroxypyruvate + H2O2 + NH4(+) - PubMed:16616139, PubMed:17303072, PubMed:18544534, PubMed:20567862, PubMed:23219954, PubMed:23391306, PubMed:25701391, PubMed:31799256, PubMed:32730563, PubMed:38035964, PubMed:20368421
left-to-right
D-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+) - PubMed:20567862
left-to-right
D-valine + O2 + H2O = 3-methyl-2-oxobutanoate + H2O2 + NH4(+) - PubMed:20567862
left-to-right
Cofactor: Evidence: Note:
FAD ECO:0000269 | PubMed:16616139
ECO:0000269 | PubMed:17088322
ECO:0000269 | PubMed:17303072
ECO:0000269 | PubMed:18455394
ECO:0000269 | PubMed:19438227
ECO:0000269 | PubMed:20521334
ECO:0000269 | PubMed:20603179
ECO:0000269 | PubMed:23566269
ECO:0000269 | PubMed:23631755
ECO:0000269 | PubMed:25001371
ECO:0000269 | PubMed:25701391
ECO:0000269 | PubMed:29274788
ECO:0000269 | PubMed:29326945
ECO:0000269 | PubMed:30265959
ECO:0000269 | PubMed:31799256
ECO:0000269 | PubMed:32730563
ECO:0000269 | PubMed:34041270
ECO:0000269 | PubMed:35482677
ECO:0000269 | PubMed:37558109
ECO:0000269 | PubMed:38035964
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