Brand  (β version)

PDB ID: 5ZJ9

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
9E6 5-chloro thiophene-3-carboxylic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5ZJ9   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : human D-amino acid oxidase complexed with 5-chlorothiophene-3-carboxylic acid
Release Data : 2018-10-10
Compound :
mol_id molecule chains synonym
1 D-amino-acid oxidase A,B,C,D DAO
ec: 1.4.3.3
fragment: UNP residues 1-240
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: DAO, DAMOX
Authors : Kato, Y., Hin, N., Maita, N., Thomas, A.G., Kurosawa, S., Rojas, C., Yorita, K., Slusher, B.S., Fukui, K., Tsukamoto, T.
Keywords : D-amino acid, flavoenzyme, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Structural basis for potent inhibition of d-amino acid oxidase by thiophene carboxylic acids

Kato, Y.,Hin, N.,Maita, N.  et al.
(2018)  Eur J Med Chem  159 : 23 - 34

PubMed: 30265959
DOI: 10.1016/j.ejmech.2018.09.040

Reaction

Chain : A, B, C, D
UniProt : P14920 (OXDA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a D-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+) 1.4.3.3 PubMed:17088322
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