Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
9C0 9-(4-~{tert}-butylphenyl)-3,4-dihydropyrido[2,1-C][1,2,4]thiadiazine 2,2-dioxide
ACT Acetate ion
GOL Glycerol
ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid
ZN Zinc ion
Code : 5ZG2
Header : TRANSPORT PROTEIN
Title : Crystal structure of the GluA2o LBD in complex with ZK200775 and Compound-2
Release Data : 2019-01-16
Compound :
mol_id molecule chains synonym
1 Glutamate receptor 2 A,B GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2
fragment: UNP residues 413-527,UNP residues 653-796
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: GLUR2
Authors : Sogabe, S., Igaki, S., Hirokawa, A., Zama, Y., Lane, W., Snell, G.
Keywords : AMPA RECEPTOR LIGAND-BINDING DOMAIN, ALLOSTERIC MODULATION COMPLEX, MEMBRANE PROTEIN, TRANSPORT PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.25 Å )
Citation :

TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.

Kunugi, A.,Tanaka, M.,Suzuki, A.  et al.
(2019)  Neuropsychopharmacology  44 : 961 - 970

PubMed: 30209408
DOI: 10.1038/s41386-018-0213-7

Chain : A, B
UniProt : P42262 (GRIA2_HUMAN)
Reaction : -