Het-PDB Navi2 (PDB: 5ZFT)

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Ligands
Code	Name		Style	Show	Link
CED	5-methyl-2-[2-oxo-1-(2-thiophen-2-yl-acetylamino)-ethyl]-3,6-dihydro-2h-[1,3]thiazine-4-carboxylic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5ZFT

Code :

5ZFT PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of beta-lactamase PenP mutant-E166Y in complex with cephaloridine as "pre-deacylation" intermediate

Release Data :

2019-03-20

Compound :

mol_id	molecule	chains	synonym
1	Beta-lactamase	A,B	Penicillinase
	ec: 3.5.2.6 mutation: E166Y

Source :

mol_id	organism_scientific	expression_system
1	Bacillus licheniformis (taxid:1402)	Escherichia coli 'BL21-Gold(DE3)pLysS AG' (taxid:866768)
	gene: penP, blaP

Authors :

Pan, X., Zhao, Y.

Keywords :

class A beta-lactamase, antibiotic resistance, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.93 Å )

Citation :

The hydrolytic water molecule of Class A beta-lactamase relies on the acyl-enzyme intermediate ES* for proper coordination and catalysis.

He, Y.,Lei, J.,Pan, X. et al.
(2020) Sci Rep 10 : 10205 - 10205

Chain :

A, B

UniProt :

P00808 (BLAC_BACLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a beta-lactam + H2O = a substituted beta-amino acid	3.5.2.6	PROSITE- ProRule:PRU10101
a beta-lactam + H2O = a substituted beta-amino acid	-	PROSITE- ProRule:PRU10101

PDB ID: 5ZFT