Het-PDB Navi2 (PDB: 5ZFI)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
9C9	2-[(3z,6r)-6-[(2,6-dichlorophenyl)methyl]-3-(dimethylhydrazinylidene)-7-oxo-1,4-diazepan-1-yl]-N-[3-(1-methyl-1h-pyrazol-4-yl)phenyl]acetamide				PoSSuM
TRS	2-amino-2-hydroxymethyl-propane-1,3-diol				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 5ZFI

Code :

5ZFI PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Mouse kallikrein 7 in complex with 6-benzyl-1,4-diazepan-7-one derivative

Release Data :

2018-06-27

Compound :

mol_id	molecule	chains	synonym
1	Kallikrein-7	A	Serine protease 6,Stratum corneum chymotryptic enzyme,Thymopsin
	ec: 3.4.21.117

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Mus musculus (taxid:10090)	Mouse	Escherichia coli (taxid:562)
	gene: Klk7, Prss6, Scce

Authors :

Sugawara, H.

Keywords :

protease, inhibitor complex, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.80 Å )

Citation :

Structure-based drug design to overcome species differences in kallikrein 7 inhibition of 1,3,6-trisubstituted 1,4-diazepan-7-ones.

Murafuji, H.,Sugawara, H.,Goto, M. et al.
(2018) Bioorg. Med. Chem. 26 : 3639 - 3653

Discovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors.

Murafuji, H.,Sakai, H.,Goto, M. et al.
(2017) Bioorg. Med. Chem. Lett. 27 : 5272 - 5276

Chain :

UniProt :

Q91VE3 (KLK7_MOUSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Cleavage of proteins with aromatic side chains in the P1 position.	3.4.21.117	-
	-	-

PDB ID: 5ZFI