Brand  (β version)

PDB ID: 5ZF7

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
CHW 3-chloro-4,6-dihydroxy-5-[(2e,6e,8s)-8-hydroxy-3,7-dimethylnona-2,6-dien-1-yl]-2-methylbenzaldehyde PoSSuM
FMN Flavin mononucleotide PoSSuM
ORO Orotic acid PoSSuM
SO4 Sulfate ion PoSSuM
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Structure summary

Code : 5ZF7   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Structure of human dihydroorotate dehydrogenase in complex with 277-9-OH
Release Data : 2018-09-26
Compound :
mol_id molecule chains synonym
1 Dihydroorotate dehydrogenase (quinone), mitochondrial A DHOdehase,Dihydroorotate oxidase
ec: 1.3.5.2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: DHODH
expression_system_strain: BL21(DE3)PYRD
Authors : Miyazaki, Y., Inaoka, K.D., Shiba, T., Saimoto, H., Amalia, E., Kido, Y., Sakai, C., Nakamura, M., Moore, L.A., Harada, S., Kita, K.
Keywords : ROSSMANN FOLD, DIHYDROOROTATE/OROTATE, UBIQUINONE/UBIQUINOL, MITOCHONDRIAL INNER MEMBRANE, INHIBITOR COMPLEX, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.79 Å )
Citation :

Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.

Miyazaki, Y.,Inaoka, D.K.,Shiba, T.  et al.
(2018)  Front Pharmacol  9 : 997 - 997

PubMed: 30233375
DOI: 10.3389/fphar.2018.00997

Reaction

Chain : A
UniProt : Q02127 (PYRD_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(S)-dihydroorotate + a quinone = orotate + a quinol 1.3.5.2 PubMed:8925840
-
Cofactor: Evidence: Note:
FMN ECO:0000269 | PubMed:10673429
Binds 1 FMN per subunit.