PDB ID: 5ZF4
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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9BL | Methyl (2e,6e)-8-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-2,6-dimethylocta-2,6-dienoate | PoSSuM | |||
ACT | Acetate ion | PoSSuM | |||
FMN | Flavin mononucleotide | PoSSuM | |||
ORO | Orotic acid | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM |
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Download interaction data: 5ZF4
Structure summary
Code : | 5ZF4 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE | ||||||||||||
Title : | Structure of human dihydroorotate dehydrogenase in complex with 275-10-COOMe | ||||||||||||
Release Data : | 2018-09-26 | ||||||||||||
Compound : |
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Source : |
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Authors : | Miyazaki, Y., Inaoka, K.D., Shiba, T., Saimoto, H., Amalia, E., Kido, Y., Sakai, C., Nakamura, M., Moore, L.A., Harada, S., Kita, K. | ||||||||||||
Keywords : | ROSSMANN FOLD, DIHYDROOROTATE/OROTATE, UBIQUINONE/UBIQUINOL, MITOCHONDRIAL INNER MEMBRANE, INHIBITOR COMPLEX, OXIDOREDUCTASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.66 Å ) | ||||||||||||
Citation : |
Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.
Miyazaki, Y.,Inaoka, D.K.,Shiba, T.
et al.
PubMed: 30233375 |
Reaction
Chain : | A | ||||||||
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UniProt : | Q02127 (PYRD_HUMAN) | ||||||||
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