Brand  (β version)

PDB ID: 5ZEQ

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Ligands
Code Name Style Show Link
9B3 (2~{S})-2-[(6-azanyl-5-chloranyl-pyridin-3-yl)methyl]-3-selanyl-propanoic acid PoSSuM
CAC Cacodylate ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 5ZEQ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/INHIBITOR
Title : Carboxypeptidase B in complex with DD28
Release Data : 2018-06-20
Compound :
mol_id molecule chains
1 Carboxypeptidase B A
ec: 3.4.17.2
Source :
mol_id organism_scientific organism_common expression_system
1 Sus scrofa  (taxid:9823) Pig Sus scrofa  (taxid:9823)
gene: CPB1, CPB
Authors : Itoh, T., Yoshimoto, N., Yamamoto, K.
Keywords : selenium, organoselenium, selenol, CPB inhibitor, selectivity, HYDROLASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.9000 Å )
Citation :

Structural basis for the selective inhibition of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) by a selenium-containing inhibitor with chloro-aminopyridine as a basic group

Itoh, T.,Yoshimoto, N.,Hirano, Y.  et al.
(2018)  Bioorg. Med. Chem. Lett.  28 : 2256 - 2260

PubMed: 29859906
DOI: 10.1016/j.bmcl.2018.05.042

Reaction

Chain : A
UniProt : P09955 (CBPB1_PIG)
Reaction: EC: Evidence:
Physiological Direction:
Preferential release of a C-terminal lysine or arginine amino acid. 3.4.17.2 UniProtKB:P00732
-
Cofactor: Evidence: Note:
Zn(2+) ECO:0000250 | UniProtKB:P15086
Binds 1 zinc ion per subunit.