Het-PDB Navi2 (PDB: 5ZC5)

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Ligands
Code	Name		Style	Show	Link
09I	3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(4-fluoranyl-1-benzofuran-2-yl)pyrazine-2-carboxamide				PoSSuM

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Download interaction data: 5ZC5

Code :

5ZC5 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

uPA-NU-09F

Release Data :

2018-12-19

Compound :

mol_id	molecule	chains	synonym
1	Urokinase-type plasminogen activator chain B	U	uPA
	ec: 3.4.21.73 mutation: C122A, N145Q

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Komagataella pastoris (taxid:4922)
	gene: PLAU

Authors :

Jiang, L.G., Buckley, B.J., Huang, M.D., Kelso, M.J., Ranson, M.

Keywords :

uPA, Inhibitor, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.90 Å )

Citation :

6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.

Buckley, B.J.,Aboelela, A.,Minaei, E. et al.
(2018) J. Med. Chem. 61 : 8299 - 8320

PubMed: 30130401
DOI: 10.1021/acs.jmedchem.8b00838

Chain :

UniProt :

P00749 (UROK_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Specific cleavage of Arg-\|-Val bond in plasminogen to form plasmin.	3.4.21.73	-
	-	-

PDB ID: 5ZC5

Hetero Atom Contents

Structure summary

Reaction