Brand  (β version)

PDB ID: 5ZAN

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Ligands
Code Name Style Show Link
9A6 7-(4-methylpiperazin-1-yl)-N-(5-methyl-1h-pyrazol-3-yl)-2-[(E)-2-phenylethenyl]quinazolin-4-amine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5ZAN   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/INHIBITOR
Title : Crystal Structure of Aurora-A in complex with a new Quinazoline inhibitor
Release Data : 2019-02-13
Compound :
mol_id molecule chains synonym
1 Aurora kinase A A Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A
ec: 2.7.11.1
fragment: Catalytic domain, UNP residues 123-403
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
Authors : Cheng, B., Lu, G., Zhou, H.
Keywords : Drug Design, TRANSFERASE, TRANSFERASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.85 Å )
Citation :

Optimization of Novel Quinazolines as Potent and Orally Bioavailable Aurora Kinase Inhibitors

Long, L.,Peng, W.,Pan, Y.  et al.
To Be Published 

Reaction

Chain : A
UniProt : O14965 (AURKA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
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