Brand  (β version)

PDB ID: 5Z9F

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Ligands
Code Name Style Show Link
PO4 Phosphate ion PoSSuM
0R0 2-hydroxybenzonitrile PoSSuM
AX7 1h-benzimidazol-2-amine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5Z9F   PDBj   RCSB PDB   PDBe
Header : ISOMERASE
Title : Bacterial GyrB ATPase domain in complex with a chemical fragment
Release Data : 2018-12-12
Compound :
mol_id molecule chains synonym
1 DNA gyrase subunit B A,B Type IIA topoisomerase subunit GyrB
ec: 5.99.1.3
fragment: UNP residues 15-221
Source :
mol_id organism_scientific expression_system
1 Escherichia coli (strain K12)  (taxid:83333) Escherichia coli  (taxid:562)
strain: K12
gene: gyrB, acrB, cou, himB, hisU, nalC, parA, pcbA, b3699, JW5625
Authors : Huang, X., Zhou, H.
Keywords : DNA Topoisomerase, Antibacterial, Drug Target, Fragment-base Lead Discovery, ISOMERASE
Exp. method : X-RAY DIFFRACTION ( 1.76 Å )
Citation :

Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes

Huang, X.,Guo, J.,Liu, Q.  et al.
(2018)  Medchemcomm  9 : 1619 - 1629

PubMed: 30429968
DOI: 10.1039/c8md00148k

Reaction

Chain : A, B
UniProt : P0AES6 (GYRB_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
ATP-dependent breakage, passage and rejoining of double- stranded DNA. 5.6.2.2 HAMAP-Rule:MF_01898, PubMed:12051842, PubMed:12051843, PubMed:18642932, PubMed:186775, PubMed:19965760, PubMed:20675723, PubMed:22731783
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