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Ligands
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JIA (2~{R},3~{R},4~{R},5~{R})-2-[(1~{S},2~{S},3~{R},4~{S},6~{R})-3-[(2~{R},3~{R},4~{R},5~{S},6~{R})-6-(aminomethyl)-3-azany L-4,5-bis(oxidanyl)oxan-2-yl]oxy-4,6-bis(azanyl)-2-oxidanyl-cyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol
PLP Pyridoxal-5'-phosphate
Non-standard Residues
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Glycosylation
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Modification
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Code : 5Z8A   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of GenB1 from Micromonospora echinospora in complex with JI-20A and PLP (external aldimine)
Release Data : 2019-01-16
Compound :
mol_id molecule chains synonym
1 C-6' aminotransferase A,B Gentamicin (Hexosaminyl-6-) aminotransferase I,GntW,Putative glutamate-1-semialdehyde aminotransferase
Source :
mol_id organism_scientific organism_common expression_system
1 Micromonospora echinospora  (taxid:1877) Micromonospora purpurea Escherichia coli  (taxid:562)
gene: gacK, genB1, gntW
Authors : Hong, S.K., Cha, S.S.
Keywords : Aminotransferase, PLP-binding, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.3980 Å )
Citation :

Complete reconstitution of the diverse pathways of gentamicin B biosynthesis.

Ban, Y.H.,Song, M.C.,Hwang, J.Y.  et al.
(2019)  Nat. Chem. Biol.  15 : 295 - 303

PubMed: 30643280
DOI: 10.1038/s41589-018-0203-4

Chain : A, B
UniProt : Q70KD9 (Q70KD9_MICEC)
Reaction : -