Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
96R 2-amino-4-(1h-imidazol-1-yl)quinolin-8-ol
Code : 5Z5T
Header : TRANSCRIPTION/INHIBITOR
Title : The first bromodomain of BRD4 with compound BDF-2141
Release Data : 2019-01-23
Compound :
mol_id molecule chains synonym
1 Bromodomain-containing protein 4 A Protein HUNK1
fragment: first bromodomain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: BRD4, HUNK1
Authors : Zhang, H., Luo, C.
Keywords : BRD4, Inhibitor, Complex, PROTEIN BINDING, TRANSCRIPTION-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.991 Å )
Citation :

Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma.

Chen, W.,Zhang, H.,Chen, Z.  et al.
(2018)  Oncogenesis  7 : 83 - 83

PubMed: 30385738
DOI: 10.1038/s41389-018-0093-z

Chain : A
UniProt : O60885 (BRD4_HUMAN)
Reaction : -