Brand  (β version)

PDB ID: 5Z4U

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Ligands
Code Name Style Show Link
96C 4-(4-ethoxyphenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)-1h-pyrazole PoSSuM
ACP Phosphomethylphosphonic acid adenylate ester PoSSuM
CA Calcium ion PoSSuM
GDP Guanosine-5'-diphosphate PoSSuM
GTP Guanosine-5'-triphosphate PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 5Z4U   PDBj   RCSB PDB   PDBe
Header : STRUCTURAL PROTEIN
Title : Crystal Structure of T2R-TTL complex with 7a3
Release Data : 2019-01-23
Compound :
mol_id molecule chains synonym
1 Tubulin alpha-1B chain A,C Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
mol_id molecule chains
2 Tubulin beta-2B chain B,D
mol_id molecule chains synonym
3 Stathmin-4 E Stathmin-like protein B3,RB3
mol_id molecule chains
4 Tubulin tyrosine ligase F
Source :
mol_id organism_scientific organism_common expression_system
1 Sus scrofa  (taxid:9823) Pig Escherichia coli  (taxid:562)
gene: TUBA1B
mol_id organism_scientific organism_common expression_system
2 Bos taurus  (taxid:9913) Bovine Escherichia coli  (taxid:562)
gene: TUBB2B
mol_id organism_scientific organism_common expression_system
3 Rattus norvegicus  (taxid:10116) Rat Escherichia coli  (taxid:562)
gene: Stmn4
mol_id organism_scientific organism_common expression_system
4 Gallus gallus  (taxid:9031) Chicken Escherichia coli  (taxid:562)
gene: TTL
Authors : Lai, Q., Wang, Y., Yang, J., Yao, Y.
Keywords : TUBULIN, COMPLEX, INHIBITOR, STRUCTURAL PROTEIN
Exp. method : X-RAY DIFFRACTION ( 3.18 Å )
Citation :

Crystal Structure of T2R-TTL complex with 7a3

Lai, Q.,Wang, Y.,Yang, J.  et al.
To Be Published 

Reaction

Chain : A, C
UniProt : Q2XVP4 (TBA1B_PIG)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + phosphate + H(+) - UniProtKB:P68363
left-to-right
Cofactor: Evidence: Note:
Mg(2+) ECO:0000250 | UniProtKB:P68363
-
Chain : B, D
UniProt : Q6B856 (TBB2B_BOVIN)
Reaction : -
Cofactor: Evidence: Note:
Mg(2+) ECO:0000250 | UniProtKB:P68363
-
Chain : E
UniProt : P63043 (STMN4_RAT)
Reaction : -
Chain : F
UniProt : E1BQ43
Reaction : -