Brand  (β version)

PDB ID: 5Z1D

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Ligands
Code Name Style Show Link
95U N-[3-(6-methyl-1h-indazol-3-yl)phenyl]prop-2-enamide PoSSuM
EPE 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5Z1D   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : MAP2K7 C276S mutant-inhibitor
Release Data : 2019-01-02
Compound :
mol_id molecule chains synonym
1 Dual specificity mitogen-activated protein kinase kinase 7 A MAPKK 7,JNK-activating kinase 2,MAPK/ERK kinase 7,MEK 7,Stress-activated protein kinase kinase 4,SAPKK4,c-Jun N-terminal kinase kinase 2,JNKK 2
ec: 2.7.12.2
fragment: UNP residues 103-419
mutation: C276S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli B  (taxid:37762)
gene: MAP2K7, JNKK2, MEK7, MKK7, PRKMK7, SKK4
Authors : Kinoshita, T., London, N.
Keywords : protein kinase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.28 Å )
Citation :

Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor.

Shraga, A.,Olshvang, E.,Davidzohn, N.  et al.
(2019)  Cell Chem Biol  26 : 98 - 108.e5

PubMed: 30449673
DOI: 10.1016/j.chembiol.2018.10.011

Reaction

Chain : A
UniProt : O14733 (MP2K7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.12.2 -
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.12.2 -
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ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.12.2 -
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