Het-PDB Navi2 (PDB: 5Z0S)

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Ligands
Code	Name		Style	Show	Link
960	1-[(6-chloroimidazo[1,2-B]pyridazin-3-yl)sulfonyl]-6-(1-methyl-1h-pyrazol-4-yl)-1h-pyrazolo[4,3-B]pyridine				PoSSuM

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Download interaction data: 5Z0S

Code :

5Z0S PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal structure of FGFR1 kinase domain in complex with a novel inhibitor

Release Data :

2018-12-26

Compound :

mol_id	molecule	chains	synonym
1	Fibroblast growth factor receptor 1	A,B	FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr
	ec: 2.7.10.1 fragment: UNP residues 458-765 mutation: C488A, C584S

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR

Authors :

Liu, Q., Xu, Y.

Keywords :

FGFR1 inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.4500 Å )

Citation :

Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors

Jiang, A.,Liu, Q.,Wang, R. et al.
(2018) Molecules 23

Chain :

A, B

UniProt :

P11362 (FGFR1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:1379697, PubMed:15117958, PubMed:18480409, PubMed:19224897, PubMed:19665973, PubMed:20133753, PubMed:8622701
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PDB ID: 5Z0S