Brand  (β version)

PDB ID: 5YZ3

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Ligands
Code Name Style Show Link
94U N-[4-(diethylamino)phenyl]-4h-pyrrolo[2,3-D][1,3]thiazole-5-carboxamide PoSSuM
ACP Phosphomethylphosphonic acid adenylate ester PoSSuM
CA Calcium ion PoSSuM
CL Chloride ion PoSSuM
GDP Guanosine-5'-diphosphate PoSSuM
GOL Glycerol PoSSuM
GTP Guanosine-5'-triphosphate PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
MG Magnesium ion PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5YZ3   PDBj   RCSB PDB   PDBe
Header : CELL CYCLE
Title : Crystal structure of T2R-TTL-28 complex
Release Data : 2018-10-24
Compound :
mol_id molecule chains synonym
1 Tubulin alpha-1B chain A,C Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
mol_id molecule chains
2 Tubulin beta-2B chain B,D
mol_id molecule chains synonym
3 Stathmin-4 E Stathmin-like protein B3,RB3
fragment: SLD
mol_id molecule chains
4 Tubulin Tyrosine Ligase F
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Bovine
mol_id organism_scientific organism_common
2 Bos taurus  (taxid:9913) Bovine
mol_id organism_scientific organism_common expression_system
3 Rattus norvegicus  (taxid:10116) Rat Escherichia coli  (taxid:562)
gene: Stmn4
mol_id organism_scientific organism_common expression_system
4 Gallus gallus  (taxid:9031) Chicken Escherichia coli  (taxid:562)
gene: TTL
Authors : Yu, Y., Chen, Q.
Keywords : Tubulin, Complex, STRUCTURAL PROTEIN-INHIBITOR complex, STRUCTURAL PROTEIN, CELL CYCLE
Exp. method : X-RAY DIFFRACTION ( 2.545 Å )
Citation :

A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors.

Ning, N.,Yu, Y.,Wu, M.  et al.
(2018)  Cancer Res.  78 : 5949 - 5957

PubMed: 30135190
DOI: 10.1158/0008-5472.CAN-18-0455

Reaction

Chain : A, C
UniProt : P81947 (TBA1B_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + phosphate + H(+) - UniProtKB:P68363
left-to-right
Cofactor: Evidence: Note:
Mg(2+) ECO:0000250 | UniProtKB:P68363
-
Chain : B, D
UniProt : Q6B856 (TBB2B_BOVIN)
Reaction : -
Cofactor: Evidence: Note:
Mg(2+) ECO:0000250 | UniProtKB:P68363
-
Chain : E
UniProt : P63043 (STMN4_RAT)
Reaction : -
Chain : F
UniProt : E1BQ43
Reaction : -