Het-PDB Navi2 (PDB: 5YYF)

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Ligands
Code	Name		Style	Show	Link
SO4	Sulfate ion				PoSSuM
FOA	2-furoic acid				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
PHQ	Benzyl chlorocarbonate
NH2	Amino group

Download interaction data: 5YYF

Code :

5YYF PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION

Title :

Crystal structure of AF9 YEATS domain in complex with a peptide inhibitor "PHQ-H3(Q5-K9)" modified at K9 with 2-furancarboyl group

Release Data :

2018-11-07

Compound :

mol_id	molecule	chains	synonym
1	Protein AF-9	A,C	ALL1-fused gene from chromosome 9 protein,Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein,YEATS domain-containing protein 3

mol_id	molecule	chains
2	Peptide inhibitor PHQ-H3(Q5-K9)	B,D

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: MLLT3, AF9, YEATS3 expression_system_strain: BL21(DE3) expression_system_plasmid: pET-28b

mol_id	organism_scientific
2	Homo sapiens (taxid:9606)
	synthetic: yes

Authors :

Li, Y., Li, H.

Keywords :

YEATS domain, Complex, Inhibitor, 2-furancarboyl group, TRANSCRIPTION

Exp. method :

X-RAY DIFFRACTION ( 1.903 Å )

Citation :

Structure-guided development of YEATS domain inhibitors by targeting pi-pi-pi stacking.

Li, X.,Li, X.M.,Jiang, Y. et al.
(2018) Nat. Chem. Biol. 14 : 1140 - 1149

PDB ID: 5YYF