Brand  (β version)

PDB ID: 5YWK

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Ligands
Code Name Style Show Link
92X 1,5-dimethyl-3-(2-methylphenyl)-6-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-quinazoline-2,4-dione PoSSuM
CO Cobalt (II) ion PoSSuM
Non-standard Residues
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Structure summary

Code : 5YWK   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of Arabidopsis thaliana HPPD complexed with Benquitrione-Methyl
Release Data : 2019-01-16
Compound :
mol_id molecule chains synonym
1 4-hydroxyphenylpyruvate dioxygenase A,B 4-hydroxyphenylpyruvic acid oxidase,HPPDase
ec: 1.13.11.27
Source :
mol_id organism_scientific organism_common expression_system
1 Arabidopsis thaliana  (taxid:3702) Mouse-ear cress Escherichia coli 'BL21-Gold(DE3)pLysS AG'  (taxid:866768)
gene: HPD, PDS1, At1g06570, F12K11.9
expression_system_strain: BL21-Gold(DE3)pLysS AG
Authors : Yang, W.C., Lin, H.Y.
Keywords : 4-hydroxyphenylpyruvate dioxygenase, Herbicide, drug discovery, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.804 Å )
Citation :

Structure-Guided Discovery of Silicon-Containing Subnanomolar Inhibitor of Hydroxyphenylpyruvate Dioxygenase as a Potential Herbicide.

Qu, R.Y.,Nan, J.X.,Yan, Y.C.  et al.
(2021)  J.Agric.Food Chem.  69 : 459 - 473

PubMed: 33395281
DOI: 10.1021/acs.jafc.0c03844

Reaction

Chain : A, B
UniProt : P93836 (HPPD_ARATH)
Reaction: EC: Evidence:
Physiological Direction:
3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate 1.13.11.27 PubMed:15301540
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