Brand  (β version)

PDB ID: 5YWG

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Ligands
Code Name Style Show Link
92L 2-[(4-methylsulfonyl-2-nitro-phenyl)-oxidanyl-methylidene]cyclohexane-1,3-dione PoSSuM
CO Cobalt (II) ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5YWG   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of Arabidopsis thaliana HPPD complexed with Mesotrione
Release Data : 2019-01-16
Compound :
mol_id molecule chains synonym
1 4-hydroxyphenylpyruvate dioxygenase A,B 4-hydroxyphenylpyruvic acid oxidase,HPPDase
ec: 1.13.11.27
Source :
mol_id organism_scientific organism_common expression_system
1 Arabidopsis thaliana  (taxid:3702) Mouse-ear cress Escherichia coli 'BL21-Gold(DE3)pLysS AG'  (taxid:866768)
gene: HPD, PDS1, At1g06570, F12K11.9
expression_system_strain: BL21-Gold(DE3)pLysS AG
Authors : Lin, H.Y., Yang, W.C.
Keywords : Dioxygenase, Mesotrione, Tyrosine metabolism, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.603 Å )
Citation :

Molecular insights into the mechanism of 4-hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X-ray crystallography and computational simulations.

Lin, H.Y.,Yang, J.F.,Wang, D.W.  et al.
(2019)  FEBS J.  286 : 975 - 990

PubMed: 30632699
DOI: 10.1111/febs.14747

Reaction

Chain : A, B
UniProt : P93836 (HPPD_ARATH)
Reaction: EC: Evidence:
Physiological Direction:
3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate 1.13.11.27 PubMed:15301540
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