Brand  (β version)

PDB ID: 5YT2

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Ligands
Code Name Style Show Link
90O (1r,2s,3r)-5-[(E)-2-[(1r,3as,7ar)-7a-methyl-1-[(2r)-6-methyl-6-oxidanyl-heptan-2-yl]-1,2,3,3a,6,7-hexahydroinden-4-yl]ethenyl]-2-(3-oxidanylpropyl)cyclohex-4-ene-1,3-diol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5YT2   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal structure of the human vitamin D receptor ligand binding domain complexed with (1R,2S,3R)-5-[(E)-2-{(1R,3aS,7aR)-1-[(R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl}vinyl]-2-(3-hydroxypropyl)cyclohex-4-ene-1,3-diol
Release Data : 2018-04-11
Compound :
mol_id molecule chains synonym
1 Vitamin D3 receptor A VDR,1,25-dihydroxyvitamin D3 receptor,Nuclear receptor subfamily 1 group I member 1
fragment: ligand binding domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: VDR, NR1I1
Authors : Takimoto-Kamimura, M., Kakuda, S.
Keywords : Active ligand, Complex, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Effects of 2-substitution on 14-epi-19-nortachysterol-mediated biological events: based on synthesis and X-ray co-crystallographic analysis with the human vitamin D receptor.

Sawada, D.,Kakuda, S.,Takeuchi, A.  et al.
(2018)  Org. Biomol. Chem.  16 : 2448 - 2455

PubMed: 29560490
DOI: 10.1039/C8OB00158H

Reaction

Chain : A
UniProt : P11473 (VDR_HUMAN)
Reaction : -