Brand  (β version)

PDB ID: 5YSU

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
F2X (2~{R})-2-methyl-5-oxidanyl-2,3-dihydronaphthalene-1,4-dione PoSSuM
GTP Guanosine-5'-triphosphate PoSSuM
MG Magnesium ion PoSSuM
NA Sodium ion PoSSuM
NO3 Nitrate ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 5YSU   PDBj   RCSB PDB   PDBe
Header : TRANSPORT PROTEIN
Title : Plumbagin in complex with CRM1-RanM189D-RanBP1
Release Data : 2018-11-21
Compound :
mol_id molecule chains synonym
1 GTP-binding nuclear protein Ran A Androgen receptor-associated protein 24,GTPase Ran,Ras-like protein TC4,Ras-related nuclear protein
mutation: M189D
mol_id molecule chains synonym
2 Ran-specific GTPase-activating protein 1 B Chromosome stability protein 20,Perinuclear array-localized protein,Ran-binding protein 1,RANBP1
fragment: Ran Binding Domain
mol_id molecule chains synonym
3 Exportin-1,Exportin-1 C Chromosome region maintenance protein 1,Karyopherin-124,Chromosome region maintenance protein 1,Karyopherin-124
mutation: D537G,T539C,V540E,K541Q,Y1022C
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: RAN, ARA24, OK/SW-cl.81
expression_system_vector_type: plasmid
expression_system_plasmid: pET15b
mol_id organism_scientific organism_common expression_system
2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast Escherichia coli BL21(DE3)  (taxid:469008)
strain: ATCC 204508 / S288c
gene: YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08
expression_system_vector_type: plasmid
expression_system_plasmid: pGEX4t-1
mol_id organism_scientific organism_common expression_system
3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast Escherichia coli BL21(DE3)  (taxid:469008)
strain: ATCC 204508 / S288c
gene: CRM1, KAP124, XPO1, YGR218W, G8514
expression_system_vector_type: plasmid
expression_system_plasmid: pGEX4t-1
Authors : Sun, Q., Zhang, Y.
Keywords : Active Ran, Complex, TRANSPORT PROTEIN, inhibitor
Exp. method : X-RAY DIFFRACTION ( 2.3000 Å )
Citation :

RanL182A in complex with RanBP1-CRM1

Sun, Q.,Zhang, Y.
To Be Published 

Reaction

Chain : A
UniProt : P62826 (RAN_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + H(+) + phosphate - PubMed:26272610, PubMed:8636225
left-to-right
Chain : B
UniProt : P41920 (YRB1_YEAST)
Reaction : -
Chain : C
UniProt : P30822 (XPO1_YEAST)
Reaction : -