Het-PDB Navi2 (PDB: 5YSO)

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Ligands
Code	Name		Style	Show	Link
90C	4-[5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol				PoSSuM

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Download interaction data: 5YSO

Code :

5YSO PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION

Title :

Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domain with DN200434

Release Data :

2018-12-26

Compound :

mol_id	molecule	chains	synonym
1	Estrogen-related receptor gamma	A,B,C	ERR gamma-2,Estrogen receptor-related protein 3,Nuclear receptor subfamily 3 group B member 3

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: ESRRG, ERR3, ERRG2, KIAA0832, NR3B3

Authors :

Cho, S.J., Chin, J.W., Yoon, H.S., Jeon, Y.H., Bae, J.H., Song, J.Y.

Keywords :

Sodium iodide symporter (NIS), Anaplastic thyroid cancer, Estrogen-related receptor gamma, Radioiodine therapy, TRANSCRIPTION

Exp. method :

X-RAY DIFFRACTION ( 2.501 Å )

Citation :

A Novel Orally Active Inverse Agonist of Estrogen-related Receptor Gamma (ERR gamma ), DN200434, A Booster of NIS in Anaplastic Thyroid Cancer.

Singh, T.D.,Song, J.,Kim, J. et al.
(2019) Clin.Cancer Res. 25 : 5069 - 5081

PDB ID: 5YSO