Het-PDB Navi2 (PDB: 5YLU)

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Ligands
Code	Name	Link
CE1	O-dodecanyl octaethylene glycol	PoSSuM
HKT	1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonyl-pyrrol-3-yl]-~{N}-methyl-methanamine	PoSSuM
MG	Magnesium ion	PoSSuM
PCW	1,2-dioleoyl-sn-glycero-3-phosphocholine	PoSSuM

Non-standard Residues
Code	Name	Show
BFD	Aspartate beryllium trifluoride

Glycosylation
Code	Name	Emphasize
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
Code	Name	Show

Download interaction data: 5YLU

Code :

5YLU PDBj RCSB PDB PDBe

Header :

MEMBRANE PROTEIN

Title :

Crystal structure of the gastric proton pump complexed with vonoprazan

Release Data :

2018-04-11

Compound :

mol_id	molecule	chains	synonym
1	Potassium-transporting ATPase alpha chain 1	A	Gastric H(+)/K(+) ATPase subunit alpha,Proton pump
	ec: 3.6.3.10 mutation: R220C, S593C, G1005S

mol_id	molecule	chains	synonym
2	Potassium-transporting ATPase subunit beta	B	Gastric H(+)/K(+) ATPase subunit beta,Proton pump beta chain,gp60-90

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Sus scrofa (taxid:9823)	Pig	Homo sapiens (taxid:9606)
	gene: ATP4A expression_system_cell_line: HEK293S GnT1- expression_system_vector_type: Baculovirus expression_system_plasmid: pFB-based

mol_id	organism_scientific	organism_common	expression_system
2	Sus scrofa (taxid:9823)	Pig	Homo sapiens (taxid:9606)
	gene: ATP4B expression_system_cell_line: HEK293S GnT1-

Authors :

Abe, K., Irie, K., Nakanishi, H., Fujiyoshi, Y.

Keywords :

gastric, proton pump, H+, K+-ATPase, P-type ATPase, transporter, MEMBRANE PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.79988962319 Å )

Citation :

Crystal structures of the gastric proton pump

Abe, K.,Irie, K.,Nakanishi, H. et al.
(2018) Nature 556 : 214 - 218

Chain :

UniProt :

P19156 (ATP4A_PIG)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + H(+)(in) + H2O + K(+)(out) = ADP + 2 H(+)(out) + K(+)(in) + phosphate	7.2.2.19	UniProtKB:P09626, PubMed:19387495, PubMed:29618813, PubMed:30143663, PubMed:31436534
	left-to-right	UniProtKB:P09626

PDB ID: 5YLU