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Ligands
Code Name Style Show Link
9ON (2~{S})-2-methylpentanedioic acid
AKR Acrylic acid
GOL Glycerol
HIU (2r)-3-hydroxy-2-methylpropanoic acid
NAD Nicotinamide-adenine-dinucleotide
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Code : 5Y8M   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Mycobacterium tuberculosis 3-Hydroxyisobutyrate dehydrogenase (MtHIBADH) + NAD + (R)-3-hydroxyisobutyrate (R-HIBA)
Release Data : 2018-07-11
Compound :
mol_id molecule chains synonym
1 Probable 3-hydroxyisobutyrate dehydrogenase A,B HIBADH
ec: 1.1.1.31
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)  (taxid:83332) Escherichia coli BL21(DE3)  (taxid:469008)
strain: ATCC 25618 / H37Rv
gene: mmsB, Rv0751c, MTV041.25c
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pET22b
Authors : Srikalaivani, R., Singh, A., Surolia, A., Vijayan, M.
Keywords : 3-Hydroxy acid Dehydrogenase, Enzyme substrate interactions, Mechanism of enzyme action, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.04 Å )
Citation :

Structure, interactions and action ofMycobacterium tuberculosis3-hydroxyisobutyric acid dehydrogenase.

Srikalaivani, R.,Singh, A.,Vijayan, M.  et al.
(2018)  Biochem. J.  475 : 2457 - 2471

PubMed: 29959185
DOI: 10.1042/BCJ20180271

Chain : A, B
UniProt : P9WNY5 (MMSB_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3- oxopropanoate + H(+) + NADH 1.1.1.31 -
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