Brand  (β version)

PDB ID: 5XEZ

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Ligands
Code Name Style Show Link
97V 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1h-tetrazol-5-yl)benzamide PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 5XEZ   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Structure of the Full-length glucagon class B G protein-coupled receptor
Release Data : 2017-05-24
Compound :
mol_id molecule chains synonym
1 Glucagon receptor,Endolysin,Glucagon receptor A,B GL-R,Lysis protein,Lysozyme,Muramidase,GL-R
ec: 3.2.1.17
fragment: UNP RESIDUES 27-256,UNP RESIDUES 2-161,UNP RESIDUES 260-432
mutation: C54T, C97A
mol_id molecule chains
2 Antibody, mAb1, heavy chain C,H
mol_id molecule chains
3 Antibody, mAb1, light chain D,L
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: GCGR
expression_system_common: Fall armyworm
expression_system_vector_type: BACULOVIRUS
mol_id organism_scientific expression_system
2 Homo sapiens  (taxid:9606) Homo sapiens  (taxid:9606)
expression_system_cell_line: HEK293
mol_id organism_scientific expression_system
3 Homo sapiens  (taxid:9606) Homo sapiens  (taxid:9606)
expression_system_cell_line: HEK293
Authors : Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B.
Keywords : Human GCGR receptor, Class B, 7TM domain, membrane, LCP, XFEL, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 3.00 Å )
Citation :

Structure of the full-length glucagon class B G-protein-coupled receptor.

Zhang, H.,Qiao, A.,Yang, D.  et al.
(2017)  Nature  546 : 259 - 264

PubMed: 28514451
DOI: 10.1038/nature22363

Reaction

Chain : A, B
UniProt : P47871 (GLR_HUMAN)
Reaction : -
Chain : A, B
UniProt : D9IEF7 (D9IEF7_BPT4)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3.2.1.17 ARBA:ARBA00000632, HAMAP-Rule:MF_04110, RuleBase:RU003788
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