Brand  (β version)

PDB ID: 5XEW

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Ligands
Code Name Style Show Link
CPH (1s)-5-deoxy-1-O-methyl-1-C-[(2r,3s)-3,5,7,10-tetrahydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl]-D-xylulose PoSSuM
NI Nickel (II) ion PoSSuM
1GL 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose PoSSuM
ARI (2r,3r,6r)-6-hydroxy-2-methyltetrahydro-2h-pyran-3-yl acetate PoSSuM
CDR (2r,5s,6r)-6-methyltetrahydro-2h-pyran-2,5-diol PoSSuM
ERI 3-C-methyl-4-O-acetyl-alpha-L-olivopyranose PoSSuM
: Polysaccharide
Non-standard Residues
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Structure summary

Code : 5XEW   PDBj   RCSB PDB   PDBe
Header : DNA/ANTIBIOTIC
Title : Crystal structure of the [Ni2+-(chromomycin A3)2]-CCG repeats complex
Release Data : 2017-06-21
Compound :
mol_id molecule chains
1 DNA (5'-D(*TP*TP*CP*CP*GP*CP*CP*GP*CP*CP*GP*AP*A)-3') A,B
Source :
mol_id organism_scientific
1 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Tseng, W.H., Wu, P.C., Hou, M.H.
Keywords : Trinucleotide repeats, neurological disease, induced fit recognition, metal binding ligand, consecutive bases flip-out, DNA deformation, molecular diagnostics, DNA-ANTIBIOTIC complex
Exp. method : X-RAY DIFFRACTION ( 1.7510 Å )
Citation :

Induced-Fit Recognition of CCG Trinucleotide Repeats by a Nickel-Chromomycin Complex Resulting in Large-Scale DNA Deformation

Tseng, W.H.,Chang, C.K.,Wu, P.C.  et al.
(2017)  Angew. Chem. Int. Ed. Engl.  56 : 8761 - 8765

PubMed: 28544401
DOI: 10.1002/anie.201703989