Brand  (β version)

PDB ID: 5XAG

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Ligands
Code Name Style Show Link
93X (3~{R},4~{R})-3-(hydroxymethyl)-4-(4-methoxy-3-oxidanyl-phenyl)-1-(3,4,5-trimethoxyphenyl)azetidin-2-one PoSSuM
ACP Phosphomethylphosphonic acid adenylate ester PoSSuM
CA Calcium ion PoSSuM
GDP Guanosine-5'-diphosphate PoSSuM
GOL Glycerol PoSSuM
GTP Guanosine-5'-triphosphate PoSSuM
IMD Imidazole PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5XAG   PDBj   RCSB PDB   PDBe
Header : STRUCTURAL PROTEIN
Title : Crystal structure of tubulin-stathmin-TTL-Compound Z2 complex
Release Data : 2018-01-03
Compound :
mol_id molecule chains synonym
1 Tubulin alpha-1B chain A,C Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
mol_id molecule chains
2 Tubulin beta-2B chain B,D
mol_id molecule chains synonym
3 Stathmin-4 E Stathmin-like protein B3,RB3
mol_id molecule chains
4 Tubulin tyrosine ligase F
Source :
mol_id organism_scientific organism_common expression_system
1 Bos taurus  (taxid:9913) Bovine Bos taurus  (taxid:9913)
mol_id organism_scientific organism_common expression_system
2 Bos taurus  (taxid:9913) Bovine Bos taurus  (taxid:9913)
gene: TUBB2B
mol_id organism_scientific organism_common expression_system
3 Rattus norvegicus  (taxid:10116) Rat Escherichia coli  (taxid:562)
gene: Stmn4
mol_id organism_scientific organism_common expression_system
4 Gallus gallus  (taxid:9031) Chicken Escherichia coli  (taxid:562)
gene: TTL
Authors : Zhang, H., Luo, C., Wang, Y.
Keywords : Tubulin, STRUCTURAL PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.56 Å )
Citation :

Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents

Zhou, P.,Liang, Y.,Zhang, H.  et al.
(2017)  Eur J Med Chem  144 : 817 - 842

PubMed: 29306206
DOI: 10.1016/j.ejmech.2017.12.004

Reaction

Chain : A, C
UniProt : P81947 (TBA1B_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + phosphate + H(+) - UniProtKB:P68363
left-to-right
Cofactor: Evidence: Note:
Mg(2+) ECO:0000250 | UniProtKB:P68363
-
Chain : B, D
UniProt : Q6B856 (TBB2B_BOVIN)
Reaction : -
Cofactor: Evidence: Note:
Mg(2+) ECO:0000250 | UniProtKB:P68363
-
Chain : E
UniProt : P63043 (STMN4_RAT)
Reaction : -
Chain : F
UniProt : E1BQ43
Reaction : -