Brand  (β version)

PDB ID: 5X7D

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Ligands
Code Name Style Show Link
8VS 4-carbamoyl-N-[(2r)-2-cyclohexyl-2-phenylacetyl]-L-phenylalanyl-3-bromo-N-methyl-L-phenylalaninamide PoSSuM
ACM Acetamide PoSSuM
BU1 1,4-butanediol PoSSuM
CAU (2s)-1-(9h-carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol PoSSuM
CLR Cholesterol PoSSuM
EPE 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 5X7D   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist
Release Data : 2017-08-16
Compound :
mol_id molecule chains synonym
1 Chimera protein of Beta-2 adrenergic receptor and Lysozyme A Beta-2 adrenoreceptor,Beta-2 adrenoceptor
fragment: UNP P07550 residues 1-230, UNP D9IEF7 residues 2-162, UNP P07550 residues 264-365
mutation: N187E, C1054T, C1097A
Source :
mol_id organism_scientific organism_common expression_system
1 Enterobacteria phage T4  (taxid:10665) Human Spodoptera frugiperda  (taxid:7108)
gene: e, T4Tp126
expression_system_common: Fall armyworm
expression_system_strain: SF9
expression_system_cell_line: SF9
expression_system_vector_type: baculovirus
expression_system_plasmid: pvl1392
Authors : Liu, X., Ahn, S., Kahsai, A.W., Meng, K.-C., Latorraca, N.R., Pani, B., Venkatakrishnan, A.J., Masoudi, A., Weis, W.I., Dror, R.O., Chen, X., Lefkowitz, R.J., Kobilka, B.K.
Keywords : GPCR, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.703 Å )
Citation :

Mechanism of intracellular allosteric beta 2AR antagonist revealed by X-ray crystal structure.

Liu, X.,Ahn, S.,Kahsai, A.W.  et al.
(2017)  Nature  548 : 480 - 484

PubMed: 28813418
DOI: 10.1038/nature23652

Reaction

Chain : A
UniProt : P07550 (ADRB2_HUMAN)
Reaction : -
Chain : A
UniProt : D9IEF7 (D9IEF7_BPT4)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3.2.1.17 ARBA:ARBA00000632, HAMAP-Rule:MF_04110, RuleBase:RU003788
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