Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0UN N-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide
Code : 5X2K   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of EGFR 696-1022 T790M in complex with WZ4003
Release Data : 2018-02-21
Compound :
mol_id molecule chains synonym
1 Epidermal growth factor receptor A Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
ec: 2.7.10.1
fragment: UNP RESIDUES 696-1022
mutation: T790M
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: EGFR, ERBB, ERBB1, HER1
expression_system_common: Fall armyworm
Authors : Zhu, S.J., Zhao, P., Yun, C.H.
Keywords : EGFR, T790M, WZ4003, WZ4002, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 3.201 Å )
Citation :

Structural insights into drug development strategy targeting EGFR T790M/C797S.

Zhu, S.J.,Zhao, P.,Yang, J.  et al.
(2018)  Oncotarget  9 : 13652 - 13665

PubMed: 29568384
DOI: 10.18632/oncotarget.24113

Chain : A
UniProt : P00533 (EGFR_HUMAN)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.