Het-PDB Navi2 (PDB: 5X2K)

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Ligands
Code	Name		Style	Show	Link
0UN	N-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide				PoSSuM

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Download interaction data: 5X2K

Code :

5X2K PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of EGFR 696-1022 T790M in complex with WZ4003

Release Data :

2018-02-21

Compound :

mol_id	molecule	chains	synonym
1	Epidermal growth factor receptor	A	Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
	ec: 2.7.10.1 fragment: UNP RESIDUES 696-1022 mutation: T790M

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: EGFR, ERBB, ERBB1, HER1 expression_system_common: Fall armyworm

Authors :

Zhu, S.J., Zhao, P., Yun, C.H.

Keywords :

EGFR, T790M, WZ4003, WZ4002, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 3.201 Å )

Citation :

Structural insights into drug development strategy targeting EGFR T790M/C797S.

Zhu, S.J.,Zhao, P.,Yang, J. et al.
(2018) Oncotarget 9 : 13652 - 13665

Chain :

UniProt :

P00533 (EGFR_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:15374980, PubMed:17349580, PubMed:18046415, PubMed:18227510, PubMed:19560417, PubMed:19563760
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PDB ID: 5X2K