Het-PDB Navi2 (PDB: 5WT4)

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Ligands
Code	Name		Style	Show	Link
C6P	N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-cysteine				PoSSuM
IPA	Isopropyl alcohol				PoSSuM

Non-standard Residues
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Download interaction data: 5WT4

Code :

5WT4 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

L-Cysteine-PLP intermediate of NifS from Helicobacter pylori

Release Data :

2017-12-13

Compound :

mol_id	molecule	chains	synonym
1	Cysteine desulfurase IscS	A	Cysteine desulfurase NifS
	ec: 2.8.1.7 mutation: L2V, K138R

Source :

mol_id	organism_scientific	expression_system
1	Helicobacter pylori (strain ATCC 700392 / 26695) (taxid:85962)	Escherichia coli (taxid:562)
	strain: ATCC 700392 / 26695 gene: iscS, HP_0220 expression_system_strain: C41(DE3) expression_system_vector_type: plasmid

Authors :

Fujishiro, T., Nakamura, R., Takahashi, T.

Keywords :

Iron-sulfur cluster biogenesis, cysteine desulfurase, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.920 Å )

Citation :

Snapshots of PLP-substrate and PLP-product external aldimines as intermediates in two types of cysteine desulfurase enzymes.

Nakamura, R.,Hikita, M.,Ogawa, S. et al.
(2019) Febs J.

Chain :

UniProt :

O25008 (ISCS_HELPY)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L- alanine	2.8.1.7	HAMAP-Rule:MF_00331
	-	HAMAP-Rule:MF_00331
Cofactor:	Evidence:	Note:
pyridoxal 5'-phosphate	ECO:0000255 \| HAMAP-Rule:MF_00331	-

PDB ID: 5WT4