Brand  (β version)

PDB ID: 5WRN

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Ligands
Code Name Style Show Link
DC 2'-deoxycytidine-5'-monophosphate PoSSuM
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Glycosylation
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Structure summary

Code : 5WRN   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human thymidylate synthase complexed with dCMP
Release Data : 2016-12-14
Compound :
mol_id molecule chains synonym
1 Thymidylate synthase B,A,C,D,E,F TSase
ec: 2.1.1.45
fragment: UNP residues 26-313
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: TYMS, TS, OK/SW-cl.29
Authors : Chen, D., Nordlund, P.
Keywords : Complex, nucleotide, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.3900 Å )
Citation :

Human thymidylate synthase complexed with dCMP

Almqvist, H.,Axelsson, H.,Jafari, R.  et al.
To Be Published 

Reaction

Chain : B, A, C, D, E, F
UniProt : P04818 (TYSY_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8- dihydrofolate + dTMP 2.1.1.45 PubMed:11278511
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