Het-PDB Navi2 (PDB: 5WMT)

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Ligands
Code	Name		Style	Show	Link
EDO	1,2-ethanediol				PoSSuM
9QY	Methyl 2-[2-(1-benzyl-1h-imidazol-2-yl)ethyl]-3-chloro-4,6-dihydroxybenzoate				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5WMT

Code :

5WMT PDBj RCSB PDB PDBe

Header :

Chaperone/Inhibitor

Title :

Structure of GRP94 N-terminal Domain bound to resorcinylic inhibitor BnIm.

Release Data :

2018-04-18

Compound :

mol_id	molecule	chains	synonym
1	Endoplasmin	A,B,C,D	94 kDa glucose-regulated protein,GRP-94,Heat shock protein 90 kDa beta member 1,94 kDa glucose-regulated protein,GRP-94,Heat shock protein 90 kDa beta member 1
	mutation: residues 287-327 are replaced with GGGG

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Canis lupus familiaris (taxid:9615)	Dog	Escherichia coli (taxid:562)
	gene: HSP90B1, GRP94, TRA1

Authors :

Que, N.S., Gewirth, D.T.

Keywords :

Chaperone, Inhibitor, Complex, Chaperone-Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.748 Å )

Citation :

Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.

Que, N.L.S.,Crowley, V.M.,Duerfeldt, A.S. et al.
(2018) J. Med. Chem. 61 : 2793 - 2805

PDB ID: 5WMT