Brand  (β version)

PDB ID: 5WKI

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
CL Chloride ion PoSSuM
CUY Tetracosyl octadecanoate PoSSuM
D3D (19s,22r,25r)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9e)-octadec-9-enoate PoSSuM
EDO 1,2-ethanediol PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
FUC Alpha-L-fucopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 5WKI   PDBj   RCSB PDB   PDBe
Header : IMMUNE SYSTEM
Title : Crystal structure of PG90 TCR-CD1b-PG complex
Release Data : 2017-11-01
Compound :
mol_id molecule chains
1 T-cell surface glycoprotein CD1b A
mol_id molecule chains
2 Beta-2-microglobulin B
mol_id molecule chains
3 T-cell receptor alpha variable 26-1,TRA@ protein D
mol_id molecule chains
4 PG90 TCR beta chain E
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Trichoplusia ni  (taxid:7111)
gene: CD1B
expression_system_strain: High Five
expression_system_vector_type: bacmid
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Trichoplusia ni  (taxid:7111)
gene: B2M, CDABP0092, HDCMA22P
expression_system_strain: High Five
expression_system_vector_type: bacmid
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: TRA@
expression_system_strain: BL21 (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET30
mol_id organism_scientific organism_common expression_system
4 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
expression_system_strain: BL21 (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET30
Authors : Shahine, A., Gras, S., Rossjohn, J.
Keywords : antigen presenting molecule, PG, phospholipid, MHC, CD1b, PG90, T-cell Receptor, TCR, autoreactive, IMMUNE SYSTEM
Exp. method : X-RAY DIFFRACTION ( 2.75 Å )
Citation :

A molecular basis of human T cell receptor autoreactivity toward self-phospholipids.

Shahine, A.,Van Rhijn, I.,Cheng, T.Y.  et al.
(2017)  Sci Immunol  2

PubMed: 29054999
DOI: 10.1126/sciimmunol.aao1384

Reaction

Chain : A
UniProt : P29016 (CD1B_HUMAN)
Reaction : -
Chain : B
UniProt : P61769 (B2MG_HUMAN)
Reaction : -
Chain : D
UniProt : A0A087WT03 (TVAZ1_HUMAN)
Reaction : -
Chain : D
UniProt : Q6P4G7 (Q6P4G7_HUMAN)
Reaction : -