Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
F50 Ethaneperoxoic acid
FAD Flavin-adenine dinucleotide
K Potassium ion
MG Magnesium ion
PXD 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-C]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide
TP9 (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate
Code : 5WJ1
Header : TRANSFERASE
Title : Crystal structure of Arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam
Release Data : 2018-02-14
Compound :
mol_id molecule chains synonym
1 Acetolactate synthase, chloroplastic A AtALS,Acetohydroxy-acid synthase,Protein CHLORSULFURON RESISTANT 1
ec: 2.2.1.6
fragment: UNP residues 86-667
Source :
mol_id organism_scientific organism_common expression_system
1 Arabidopsis thaliana  (taxid:3702) Mouse-ear cress Escherichia coli BL21(DE3)  (taxid:469008)
gene: ALS, AHAS, CSR1, TZP5, At3g48560, T8P19.70
expression_system_strain: BL21 (DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pET30a(+)
Authors : Garcia, M.D., Lonhienne, T., Guddat, L.W.
Keywords : AHAS, acetohydroxyacid synthase, acetolactate synthase, herbicide, ThDP, FAD, thiamine aminoethenethiol diphosphate, triazolopyrimidine, penoxsulam, transferase
Exp. method : X-RAY DIFFRACTION ( 2.522 Å )
Citation :

Structural insights into the mechanism of inhibition of AHAS by herbicides.

Lonhienne, T.,Garcia, M.D.,Pierens, G.  et al.
(2018)  Proc. Natl. Acad. Sci. U.S.A.  115 : E1945 - E1954

PubMed: 29440497
DOI: 10.1073/pnas.1714392115

Chain : A
UniProt : P17597 (ILVB_ARATH)
Reaction : 2 pyruvate = 2-acetolactate + CO(2).