Het-PDB Navi2 (PDB: 5WFJ)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
9Z4	4-({[3-(propanoylamino)phenyl]methyl}amino)pyrrolo[1,2-B]pyridazine-3-carboxamide				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 5WFJ

Code :

5WFJ PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

THE JAK3 KINASE DOMAIN IN COMPLEX WITH A COVALENT INHIBITOR

Release Data :

2017-10-04

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase JAK3	A	Janus kinase 3,JAK-3,Leukocyte janus kinase,L-JAK
	ec: 2.7.10.2 fragment: KINASE DOMAIN (UNP RESIDUES 810-1100) mutation: C4S, C233S, C241S

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: JAK3 expression_system_common: FALL ARMYWORM expression_system_vector_type: BACULOVIRUS TRANSFER VECTOR

Authors :

Sack, J.

Keywords :

TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.48 Å )

Citation :

Discovery of highly potent, selective, covalent inhibitors of JAK3.

Kempson, J.,Ovalle, D.,Guo, J. et al.
(2017) Bioorg. Med. Chem. Lett. 27 : 4622 - 4625

Chain :

UniProt :

P52333 (JAK3_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028
	-	PROSITE-ProRule:PRU10028

PDB ID: 5WFJ