Brand  (β version)

PDB ID: 5WCS

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Ligands
Code Name Style Show Link
MN Manganese (II) ion PoSSuM
9KU 5-hydroxy-2-[(2s)-1-{[(naphthalen-1-yl)oxy]acetyl}pyrrolidin-2-yl]-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 5WCS   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6b (SRI-29789)
Release Data : 2018-01-03
Compound :
mol_id molecule chains
1 Polymerase acidic protein A
mutation: Loop 51-72 is replaced a GGS linker, C-terminal has residual His-tag
Source :
mol_id organism_scientific expression_system
1 Influenza A virus  (taxid:641501) Escherichia coli  (taxid:469008)
strain: swl A/California/04/2009 H1N1
gene: PA
expression_system_strain: BL21(DE3)
Authors : Kumar, G., White, S.W.
Keywords : nuclease, transcription, cap-snatching, virus, HYDROLASE, hydrolase-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.5250 Å )
Citation :

Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease.

Beylkin, D.,Kumar, G.,Zhou, W.  et al.
(2017)  Sci Rep  7 : 17139 - 17139

PubMed: 29215062
DOI: 10.1038/s41598-017-17419-6

Reaction

Chain : A
UniProt : C3W5S0 (PA_I09A0)
Reaction : -
Cofactor: Evidence: Note:
Mn(2+) ECO:0000255 | HAMAP-Rule:MF_04063
ECO:0000269 | PubMed:22876177
ECO:0000269 | PubMed:26976575
ECO:0000269 | PubMed:27510745
ECO:0000269 | PubMed:29215062
Binds 2 manganese ions per subunit.