Het-PDB Navi2 (PDB: 5WCS)

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Ligands
Code	Name		Style	Show	Link
MN	Manganese (II) ion				PoSSuM
9KU	5-hydroxy-2-[(2s)-1-{[(naphthalen-1-yl)oxy]acetyl}pyrrolidin-2-yl]-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid				PoSSuM

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Download interaction data: 5WCS

Code :

5WCS PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6b (SRI-29789)

Release Data :

2018-01-03

Compound :

mol_id	molecule	chains
1	Polymerase acidic protein	A
	mutation: Loop 51-72 is replaced a GGS linker, C-terminal has residual His-tag

Source :

mol_id	organism_scientific	expression_system
1	Influenza A virus (taxid:641501)	Escherichia coli (taxid:469008)
	strain: swl A/California/04/2009 H1N1 gene: PA expression_system_strain: BL21(DE3)

Authors :

Kumar, G., White, S.W.

Keywords :

nuclease, transcription, cap-snatching, virus, HYDROLASE, hydrolase-hydrolase inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.5250 Å )

Citation :

Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease.

Beylkin, D.,Kumar, G.,Zhou, W. et al.
(2017) Sci Rep 7 : 17139 - 17139

PDB ID: 5WCS