Brand  (β version)

PDB ID: 5WBV

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
SAM S-adenosylmethionine PoSSuM
9ZY 2-chloro-5-(4-methyl-6-oxo-3-phenylpyrano[2,3-C]pyrazol-1(6h)-yl)benzoic acid PoSSuM
UNX Unknown atom or ion PoSSuM
Non-standard Residues
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Structure summary

Code : 5WBV   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/INHIBITOR
Title : Crystal Structure of the SET Domain of Human SUV420H1 In Complex With Inhibitor
Release Data : 2017-07-19
Compound :
mol_id molecule chains synonym
1 Histone-lysine N-methyltransferase KMT5B A,B Lysine N-methyltransferase 5B,Lysine-specific methyltransferase 5B,Suppressor of variegation 4-20 homolog 1,Suv4-20h1
ec: 2.1.1.43
fragment: SET domain, UNP residues 63-335
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: KMT5B, SUV420H1, CGI-85
expression_system_strain: BL21(DE3)-V3R-pRARE2
expression_system_vector_type: plasmid
expression_system_plasmid: pET28-MHL
Authors : Halabelian, L., Tempel, W., Brown, P.J., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Keywords : SET domain, methyltransferase, protein-inhibitor complex, SGC, Structural Genomics, Structural Genomics Consortium, TRANSFERASE, TRANSFERASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.3000 Å )
Citation :

Crystal Structure of the SET Domain of Human SUV420H1 In Complex With Inhibitor

Halabelian, L.,Tempel, W.,Brown, P.J.  et al.
To be published 

Reaction

Chain : A, B
UniProt : Q4FZB7 (KMT5B_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L- homocysteine + H(+) 2.1.1.362 PubMed:24396869, PubMed:28114273
left-to-right PubMed:28114273
N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L- methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S- adenosyl-L-homocysteine + H(+) - PubMed:28114273
left-to-right
L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)- methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+) 2.1.1.361 PubMed:24396869
left-to-right