Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

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Ligands
Code Name Link
9ZY 2-chloro-5-(4-methyl-6-oxo-3-phenylpyrano[2,3-C]pyrazol-1(6h)-yl)benzoic acid
SAM S-adenosylmethionine
UNX Unknown atom or ion
ZN Zinc ion
Code : 5WBV
Header : TRANSFERASE/INHIBITOR
Title : Crystal Structure of the SET Domain of Human SUV420H1 In Complex With Inhibitor
Release Data : 2017-07-19
Compound :
mol_id molecule chains synonym
1 Histone-lysine N-methyltransferase KMT5B A,B Lysine N-methyltransferase 5B,Lysine-specific methyltransferase 5B,Suppressor of variegation 4-20 homolog 1,Suv4-20h1
ec: 2.1.1.43
fragment: SET domain, UNP residues 63-335
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: KMT5B, SUV420H1, CGI-85
expression_system_strain: BL21(DE3)-V3R-pRARE2
expression_system_vector_type: plasmid
expression_system_plasmid: pET28-MHL
Authors : Halabelian, L., Tempel, W., Brown, P.J., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Keywords : SET domain, methyltransferase, protein-inhibitor complex, SGC, Structural Genomics, Structural Genomics Consortium, TRANSFERASE, TRANSFERASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.3000 Å )
Citation :

Crystal Structure of the SET Domain of Human SUV420H1 In Complex With Inhibitor

Halabelian, L.,Tempel, W.,Brown, P.J.  et al.
To be published 

Chain : A, B
UniProt : Q4FZB7 (KMT5B_HUMAN)
Reaction : S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].